Publications

Journal Articles

1.  Bridgewater, L.C., Zhang, C., Wu, Y., Zhang, Q., Hu, W., Wang, J., Li, S., Zhao, L.  “Gender-based differences in host behavior and gut microbiota composition in response to high fat diet and stress in a mouse model.”  (in preparation).

2.  Beatty, A., Bowden, A.E., Bridgewater, L.C.  “Development of complex dynamic intervertebral disc bioreactor.”  (in preparation).

3.  Cordner, R.D., Friend, L.N., Mayo, J.L., Badgley, C., Wallmann, A., Ventura, J.S., Chidsey, B.A., Rogers, A.C., Edwards, J.G., & Bridgewater, L.C.  “The nuclear variant of bone morphogenic protein 2 (nBMP2) affects cognition in a mouse model.”  (in revision).

4.  Long, W., Xue, Z., Zhang, Q., Feng, Z., Bridgewater, L.C., Wang, L., Zhao, L., Pang, X. “Differential responses of gut microbiota to the same prebiotic formula in oligotrophic and eutrophic batch fermentation systems.”  Scientific Reports 5:13469 doi: 10.1038/srep13469 http://www.nature.com/articles/srep13469 (2015).

5.  Olsen, D.S., Goar, W.A., Nichols, B.A., Bailey, K.T., Christensen, S. L., Merriam, K.R., Reynolds, P.R., Wilson, E., Weber, K.S., Bridgewater, L.C.  “Targeted mutation of nuclear bone morphogenetic protein 2 (nBMP2) impairs secondary immune response in a mouse model.”  BioMed Research International vol. 2015, Article ID 975789, doi:10.1155/2015/975789  http://www.hindawi.com/journals/bmri/2015/975789/ (2015).

6.  Zhang, C., Yin, A., Li, H., Wang, R., Wu, G., Shen, J., Zhang, M., Wang, L., Hou, Y., Ouyang, H., Zhang, Y., Zheng, Y., Wang, J., Lv, X., Wang, Y., Zhang, F., Zeng, B., Li, W., Yan, F., Zhao, Y., Pang, X., Zhang, X., Fu, H., Chen, F., Zhao, N., Hamaker, B.R., Bridgewater, L.C., Weinkove, D., Clement, K., Dore, J., Holmes, E., Xiao, H., Zhao, G., Yang, S., Bork, P., Nicholson, J.K., Wei, H., Tang, H., Zhang, X., Zhao, L.  “Dietary modulation of gut microbiota contributes to alleviation of both genetic and simple obesity in children.” EBioMedicine 2:966-982.   http://dx.doi.org/10.1016/j.ebiom.2015.07.007 (2015).

7.  Stolworthy, D.K., Bowden, A.E., Roeder, B.L., Robinson, T.F., Holland, J.G., Christensen, S.L., Beatty, A.M., Bridgewater, L.C., Eggett, D.L., Wendel, J.D., Stieger-Vanegas, S.  “MRI evaluation of spontaneous intervertebral disc degeneration in the alpaca cervical spine.” Journal of Orthopaedic Research http://onlinelibrary.wiley.com/doi/10.1002/jor.22968/full (2015).

8.  Xue, Z., Zhang, W., Wang, L., Hou, R., Zhang, M., Fei, L., Zhang, X., Huang, H., Bridgewater, L., Jiang, Y., Jiang, C., Zhao, L., Pang, X., and Zhang, Z. “The bamboo-eating giant panda harbors a carnivore-like gut microbiota, with excessive seasonal variations.”  mBio 6:3, doi: 10.1128/mBio.00022-15 http://mbio.asm.org/content/6/3/e00022-15.full (2015).

9.  Chen, H., Liu, Y., Zhang, M., Wang, G., Qi, Z., Bridgewater, L.C., Zhao, L., Tang, Z, Pang, X.  “A Filifactor alocis-centered co-occurrence group associates with periodontitis across different oral habitats.” Scientific Reports 5:9053, doi: 10.1038/srep09053 http://www.nature.com/articles/srep09053 (2015).
10.  Stolworthy, D.K., Fullwood, R.A., Merrell, T.M., Bridgewater, L.C., & Bowden, A.E.  “Biomechanical comparison of the camelid and human intervertebral disc.”  Journal of Orthopaedic Translation 3:34-43, http://dx.doi.org/10.1016/j.jot.2014.12.001 (2015).  

11.  Bridgewater, L.C., Mayo, J.L., Evanson, B.G., Whitt, M.E., Dean, S.A., Yates, J.D., Holden, D.N., Schmidt, A.D., Fox, C.L., Dhunghel, S., Steed, K.S., Adam, M.M., Nichols, C.A., Loganathan, S.K., Barrow, J.R., & Hancock, C.R.  “A novel bone morphogenetic protein 2 mutant mouse, nBmp2NLStm, displays impaired intracellular Ca2+ handling in skeletal muscle.”  BioMed Research International.  Volume 2013, article ID 125492 http://dx.doi.org/10.1155/2013/125492 (2013).

12.  Ricks, M.S., Farrell, J.T., Falk, D.J., Holt, D.W., Rees, M., Carr, J., Williams, T., Nichols, B.A., Bridgewater, L.C., Reynolds, P.R., Kooyman, D.L., & Seegmiller, R.E.  “Osteoarthritis in the temporomandibular joint of Col2a1 mutant mice.”  Archives of Oral Biology.  58:1092-1099 http://www.sciencedirect.com/science/article/pii/S0003996913000666 (2013).

13.  Holt, D.W., Henderson, M.L., Stockdale, C.E., Farrell, J.T., Kooyman, D.L., Bridgewater, L.C., & Seegmiller, R.E.  “Osteoarthritis-like changes in the heterozygous sedc mouse associated with the HtrA1-Ddr2-Mmp-13 degradative pathway:  a new model of osteoarthritis.”  Osteoarthritis and Cartilage 20:430-439 http://www.sciencedirect.com/science/article/pii/S1063458411003207 (2012).

14.  Felin, J.E., Mayo, J.L., Loos, T.J., Jensen, J.D., Sperry, D.K., Gaufin, S.K., Meinhart, C.A., Moss, J.B., Bridgewater, L.C.  “Nuclear variants of bone morphogenetic proteins.” BMC Cell Biology 11:20, http://www.biomedcentral.com/1471-2121/11/20 (2010).

15.  Muller, P., Crofts, J.D., Newman, B.S., Bridgewater, L.C., Lin, C-Y, Gustafsson, J-A, & Strom, A.  “SOX9 mediates the retinoic acid-induced HES-1 gene expression in human breast cancer cells.”  Breast Cancer Research and Treatment 120:317-326 http://link.springer.com/article/10.1007%2Fs10549-009-0381-6 (2010).

16.  Mayo, J.L., Holden, D.N., Barrow, J.R., and Bridgewater, L.C.  “The transcription factor Lc-Maf participates in Col27a1 regulation during chondrocyte maturation.”  Experimental Cell Research 315:2293-2300 http://www.sciencedirect.com/science/article/pii/S0014482709001724 (2009).

17.  Seegmiller, R.E., Bomsta, B.D., Bridgewater, L.C., Niederhauser, C.M., Montaño, C., Sudweeks, S., Eyre, D.R., and Fernandes, R.J.  “The hererozygous disproportionate micromelia (Dmm) mouse:  Morphological changes in fetal cartilage precede postnatal dwarfism and compared to lethal homozygotes can explain the mild phenotype.”  Journal of Histochemistry and Cytochemistry 56:1003-1011 http://jhc.sagepub.com/content/56/11/1003.long (2008).

18.  Genzer, M.A., Bridgewater, L.C.  “A COL9A1 enhancer element activated by two interdependent SOX9 dimers.”  Nucleic Acids Research 35:1178-1186 http://nar.oxfordjournals.org/content/35/4/1178.long (2007).

19.  Bomsta, B.D., Bridgewater, L.C., and Seegmiller, R.E.  “Premature osteoarthritis in the Disproportionate micromelia (Dmm) mouse.”  Osteoarthritis and Cartilage 14:477-485 http://www.sciencedirect.com/science/article/pii/S1063458405003250 (2006).

20.  Jenkins, E., Moss, J., Pace, J.M., and Bridgewater, L.C.  “The new collagen gene COL27A1 contains SOX9-responsive enhancer elements.”  Matrix Biology 24:177-184 http://www.sciencedirect.com/science/article/pii/S0945053X05000338 (2005).

21.  Akiyama, H., Kamitani, T., Yang, X., Kandyil, R., Bridgewater, L.C., Fellous, M., Mori-Akiyama, Y., and de Crombrugghe, B.  “The transcription factor Sox9 is degraded by the ubiquitin-proteasome system and stabilized by a mutation in a ubiquitin-target site.”  Matrix Biology 23:499-505 http://www.sciencedirect.com/science/article/pii/S0945053X04001246 (2005).

22.  Harris, L.R., Kamarainen, O., Sevakivi, M., Miller, G.C., Clarke, J.W., Potter, J.L., and Bridgewater, L.C.  “A novel retinoic acid-response element requires an enhancer element mediator for transcriptional activation.”  Biochemical Journal 383:37-43 (2004).

The above paper was featured in an accompanying online commentary by Chris P.F. Redfern, “Enhancing enhancers:  new complexities in the retinoid regulation of gene expression.”  Biochemical Journal 383:e1-e2 (2004).

23.  Rodriguez, R.R., Seegmiller, R.E., Stark, M.R., and Bridgewater, L.C.  “A type XI collagen mutation leads to increased degradation of type II collagen in articular cartilage.” Osteoarthritis and Cartilage  12:314-320 (2004).

24.  Bridgewater, L.C., Walker, M.D., Miller, G.C., Ellison, T.A., Holsinger, L.D., Potter, J.L., Jackson, T.L., Chen, R.K., Winkel, V.L., Zhang, Z., McKinney, S., and de Crombrugghe, B.  “Adjacent DNA sequences modulate Sox9 transcriptional activation at paired Sox sites in three chondrocyte-specific enhancer elements.”  Nucleic Acids Research  31:1541-1552 (2003).

25.  Ricks, J.E., Ryder, V.M., Bridgewater, L.C., Schaalje, B., and Seegmiller, R.E.  “Altered mandibular development precedes the time of palate closure in mice homozygous for disproportionate micromelia:  an oral clefting model supporting the Pierre-Robin sequence.”  Teratology 65:116-120 (2002).

26.  Bridgewater, L.C., Lefebvre, V., and de Crombrugghe, B.  “Chondrocyte-specific enhancer elements in the Col11a2 gene resemble the Col2a1 tissue-specific enhancer.”  Journal of Biological Chemistry 273:14998-15006 (1998).

27.  Bridgewater, L.C., Manning, F.C.R., and Patierno, S.R.  “Arrest of replication by mammalian DNA polymerases a and b caused by chromium-DNA lesions.”  Molecular Carcinogenesis 23:201-206 (1998).

28.  Singh, J.T., Bridgewater, L.C., and Patierno, S.R.  “Differential sensitivity of chromium-mediated DNA interstrand crosslinks and DNA-protein crosslinks to disruption by alkali and EDTA.” Toxicological Sciences 45:72-76 (1998).

29.  Bridgewater, L.C., Manning, F.C.R., and Patierno, S.R.  “Base-specific arrest of in vitro DNA replication by carcinogenic chromium: Relationship to DNA interstrand crosslinking.”  Carcinogenesis 15:2421-2427 (1994).

30.  Bridgewater, L.C., Manning, F.C.R., Woo, E.S., and Patierno, S.R.  “DNA polymerase arrest by adducted trivalent chromium.” Molecular Carcinogenesis 9:122-133 (1994).

31.  Patierno, S.R., Blankenship, L.J., Wise, J.P., Xu, J., Bridgewater, L.C., and Manning, F.C.R.  “Genotoxin-induced apoptosis: Implications for carcinogenesis.”  In Hu, V.W. (ed.) The Cell Cycle: Regulators, Targets and Clinical Applications, Plenum Press, New York, pp. 331-340 (1994).

32.  Manning, F.C.R., Blankenship, L.J., Wise, J.P., Xu, J., Bridgewater, L.C., and Patierno, S.R.  “Induction of internucleosomal DNA fragmentation by carcinogenic chromate: Relationship to DNA damage, genotoxicity, and inhibition of macromolecular synthesis.”  Environmental Health Perspectives 102:159-167 (1994).

33.  Clarke*, L., Hepworth, W.B., Carey, J.C., and Seegmiller, R.E.  “Chondrodystrophic mice with coincidental agnathia: Evidence for the tongue obstruction hypothesis in cleft palate.”  Teratology 38:565-570 (1988) [*Clarke is maiden name].